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Mutation of Tyr 180 to Ala reduced activity by ~80%, even though the side chain is far from the active site, so it is unlikely that Tyr 180 is involved in catalysis

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A similar scenario also played out on the Pacific side: low- and high-pressure systems set up in such a way as to move warm air and water from the North Pacific through the Bering Strait

While these findings shed light on the role of conformational flexibility in enzyme cooperativity, the molecular basis of this modulation remains unclear calling for further investigation into long-range structural dynamics

Yusupov, M

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